敦刻尔克

Are 3D mammograms better than standard imaging? A diverse study aims to find out_我的网站

A |     就在8月21日，快手弹指宇宙自研MMO《诡秘之主》正式公测。    Are 3D mammograms better than standard 2D imaging for catching advanced cancers?A clinical trial is recruiting thousands of volunteers — including a large number of Black women who face disparities in breast cancer death rates — to try to find out.People like Carole Stovall, a psychologist in Washington, D.C., have signed up for the study to help answer the question.“We all need a mammogram anyway, so why not do it with a study that allows the scientists to understand more and move closer to finding better treatments and ways of maybe even preventing it?” Stovall said.The underrepresentation of women and minorities in research is a long-simmering issue affecting health problems including Alzheimer’s disease, stroke and COVID-19. Trials without diversity lead to gaps in understanding of how new treatments work for all people. “Until we get more Black women into clinical trials, we can’t change the science. And we need better science for Black bodies,” said Ricki Fairley, a breast cancer survivor and advocate who is working on the issue.Black women are 40% more likely to die from breast cancer than white women and tend to be diagnosed younger. But it’s not clear whether 3D mammography is better for them, said Dr. Worta McCaskill-Stevens of the National Cancer Institute.“Are there populations for whom this might be important to have early diagnosis?" asked McCaskill-Stevens. "Or is it harmful,” causing too many false alarms or unneeded follow-up tests and treatments?McCaskill-Stevens, who is Black, leads NCI’s efforts to boost access to cancer research in minority and rural communities. She has joined the study herself.The newer 3D technique has been around for a decade, but there’s never been conclusive evidence that it's better than 2D at detecting advanced cancers. The screening technique combines multiple pictures of the breast taken from different angles to create a 3D-like image. Both 3D and 2D mammograms compress the breast and use low doses of radiation.Prior studies suggest that 3D finds more cancers than 2D, but catching more cancers doesn’t necessarily mean more lives saved. Some cancers missed by standard screening may not progress or need treatment. Previous studies did not randomly assign patients to a screening method, the gold standard for research.The notion “that if it’s new, it’s shiny, then it’s better,” isn’t necessarily true, McCaskill-Stevens said. “Until we have the evidence to support that, then we need well-designed randomized trials.”The trial has enrolled nearly 93,000 women so far with a goal of 128,000. The NCI-funded study is now running in Canada, South Korea, Peru, Argentina, Italy and 32 U.S. states. A site in Thailand will soon begin enrolling patients.“We added more international sites to enhance the trial’s diversity, particularly for Hispanic and Asian women,” said Dr. Etta Pisano, who leads the study. Overall, 42% of participants are Hispanic. As recruiting continues, enrolling Black women and other women of color will “absolutely” continue as a priority, Pisano said.Participants are randomly assigned to either 2D or 3D mammograms and are followed for several years. The number of advanced cancers detected by the two methods will be compared.At the U.S. study sites, 21% of study participants are Black women — that's higher than a typical cancer treatment study, in which 9% of participants are Black, McCaskill-Stevens said.The University of North Carolina has signed up more Black women than any other study site. Nearly a quarter of the nearly 3,000 women enrolled at UNC’s two locations are Black.“Women in North Carolina want to take part in something that’s bigger than them,” said Dr. Cherie Kuzmiak, who leads the UNC arm of the study. “They want this active role in helping determine the future of health care for women.”In Washington, D.C., word of mouth has led to successful recruiting. A chance encounter at her hair salon persuaded Stovall to join the research. While waiting for a hair appointment, she met Georgetown University cancer researcher Lucile Adams-Campbell. The two, both Black, started chatting.“She explained how important it was to get women of color into the program,” said Stovall, who jumped at the chance to catch up on her mammograms after the COVID-19 pandemic delayed screening for her and thousands of others.For Stovall, there was a personal reason to join the research. Her sister recently completed treatment for triple negative breast cancer, an aggressive type that affects Black women at higher rates than white women. Women ages 45 to 74 without a personal history of breast cancer are eligible for the study, which launched in 2017. Many women also are providing blood and cheek swab samples for a database that will be mined for insights.“It’s a dream that people had since the beginning of screening that we wouldn’t fit everybody into the same box,” Pisano said. The study's findings could “reduce disparities if we’re successful, assuming people have access to care.”Stovall, 72, had a brief scare when her mammogram, the traditional 2D type, showed something suspicious. A biopsy ruled out cancer.“I was extremely relieved,” Stovall said. “Everybody I know has heard from me about the need for them to go get a mammogram.”___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.。这款耗资12亿的游戏在开服之后热度爆表，单服排队人数接近1.4万，部分玩家要等7个多小时才能进游戏。游戏热度一路走高，登上iOS免费榜，公测第二天就冲进畅销榜TOP15。市面上多数MMO，都会等公司财报发布之后再对外公布数据。但《诡秘之主》项目组选择直接在社交平台公开开服数据：上线1小时新增用户突破100万，同时在线70万，公测第一天新增用户接近500万。游戏的火爆也带动资本市场反馈，快手股价在公测当天小幅上涨2.32%。

B | 公测第三天，官方对外公布游戏的收入情况。iOS渠道带来约15%的收入，剩下85%来自PC端和安卓官服充值，这份统计没有把B站渠道服算进去。结合公开信息，行业第三方估算，游戏上线头三天流水超过6000万。如果热度可以稳住，国服首月流水有机会突破5亿，今年之内有望实现盈利。

C | 原作小说在海外拥有不少粉丝，官方也已经规划海外版本。只要国服后续表现稳定，再加上海外版本上线，游戏有机会做到年利润10亿以上，属于2026年国产新游里表现靠前的一批产品。整个项目投入12亿，由徐杰带领624人的团队开发。游戏商城把官网直充放在显眼位置，就算需要分给阅文和原作作者一部分收益，项目依旧有不错的收入水平。按照目前流水情况估算，项目最快两个多月就能回本，慢的话大概需要3‑4个月。

D | 公测期间，官方放出9月17日新版本的福利预告，会上线外观1折券。玩家完成游戏每周任务，每个月可以拿到一张。9月1日之前注册的账号，版本更新后直接赠送两张。折扣只针对200元以下直接购买的外观，打完折最低不到1块钱。

E | 游戏收入主要来自月卡和外观，外观分为直接购买和抽卡两种形式。官方放出力度不小的外观福利，主要是应对MMO普遍会遇到的满月玩家流失问题，以此留住微氪玩家和喜欢收集时装的用户。游戏上线了不少欧式、洛丽塔风格的时装，用来吸引女性玩家。9月新版本的留存和流水表现，也会影响繁中版本、海外版本的上线节奏。从玩家的实际反馈来看，游戏目前存在两个比较突出的问题。剧情改动让一部分原著粉丝不太认可，序章战力设定、塔罗会角色的表现，都引发不少讨论，这也是IP改编游戏很容易碰到的难题。另外UE引擎带来的手机端优化问题还没解决，不少玩家转而选择PC端游玩，也间接拉高了PC和官服的收入占比。眼下游戏热度高涨，一方面是IP自带流量，另一方面市面上缺少同级别的竞品。不过MMO游戏拼的是长期运营，能不能留住原著书粉、老MMO玩家、喜欢时装的休闲玩家，是接下来的关键。现在做大型MMO成本门槛很高，项目组也提到，2026年做大型MMO，能活下来就已经算成功。游戏第二个月的留存、版本更新质量、出海进度，都会被行业持续关注。你觉得《诡秘之主》靠官服充值外加外观打折这套方式，能维持住后续的运营表现吗？欢迎在评论区留下你的看法～。

Current article:http://ncrsw7q.zhenzongtingrangunhongqiusao.shop/6dbp/20260826/584391.html

Published on:08:28:25